At DEMO SA, one of the world’s largest pharmaceutical manufacturers in injectable facilities, our new Biotechnology Center in Athens, Agios Stefanos, is now fully operational.

Biotechnology is transforming healthcare, and DEMO is at the forefront with cutting-edge research and innovation. As we continue to grow, we are looking for a high-caliber Upstream Senior Scientist to join our team.

Main duties and Responsibilities:

• Design and execute early stage as well as late-stage mammalian cell culture experiments at both lab and pilot scales.
• Hands on experience with High-throughput bioreactor systems like Ambr250.
• Perform process optimization leading to the process lock.
• Assist in the design and execution of experimental plans to understand the process and its robustness (Identification and characterization of Critical Process Parameters and their link with Critical Quality Attributes)
• Provide technical support, develop process scaleup strategies, prepare risk assessments and support technology transfer from laboratory to pilot and to commercial scale.
• Review process development, process transfer, scale-up batches and documentation.
• Perform SDM establishment and qualification & design and perform Process Characterization studies.
• Responsible for experimental data analysis and documentation
• Experienced in the DoE principles and able to analyze complex datasets using statistical tools (e.g., JMP DoE, MVDA, etc.).
• Document experimental protocols, results, and technical reports in compliance with R&D, QA & regulatory standards.

• MSc in biology, biotechnology or related field
• PhD degree in a field related to biotechnology, bioengineering or biochemistry will be highly appreciated.
• Strong background and hands-on experience 5-8 years in upstream processing of biotherapeutics (biosimilars and monoclonal antibodies preferred).
• Proficiency in operating and troubleshooting bioreactors (Lab & Pilot scale)
• Sound knowledge of regulations required for analytical development of biotech products, preferably in biosimilars development.
• Excellent communication skills both verbal and written.
• Strong problem-solving attitude, critical thinking.
• Resilience and ability to work under pressure.
• Team player.

The Company offers competitive remuneration, continuous learning and development opportunities, and a friendly and challenging working environment.